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TVB-3166

SIGMA/SML1694 - ≥98% (HPLC)

Synonym: 4-(1-(5-(3,4-Dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile

CAS Number: 1533438-83-3
Empirical Formula (Hill Notation): C24H24N4O
Molecular Weight: 384.47
Linear Formula: C24H24N4O
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1694-5MG 5 mg
$134.00
1/EA
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45-SML1694-25MG 25 mg
$543.00
1/EA
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assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string CC1=C(C2=C(C)C(C)=NN2)C=C(C(N3CC(C4=CC=C(C#N)C=C4)C3)=O)C(C)=C1
solubility DMSO: 5 mg/mL, clear (warmed)
storage condition protect from light
storage temp. 2-8°C
Biochem/physiol Actions: TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC50 <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC50 = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.o.), while exhibiting little or no anti-proliferation activity toward non-palmitate-dependent growth of cancer and non-cancer cultures. FASN inhibition by TVB-3166 treatment is also effective against the replications respiratory viruses both in cultures (Effc. conc. 200 nM against RSV and PIV3 in A549, HEp2, and HeLa cultures) and in mice (50 mg/kg/12 h, p.o.; RSV) in vivo without significant adverse effects to the host cells or mice.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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