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RSV604

SIGMA/SML1695 - ≥98% (HPLC)

Synonym: (S)-1-(2-Fluorophenyl)-3-(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-urea; RSV-604

CAS Number: 676128-63-5
Empirical Formula (Hill Notation): C22H17FN4O2
Molecular Weight: 388.39
MDL Number: MFCD28963952
Linear Formula: C22H17FN4O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1695-5MG 5 mg
$108.00
1/EA
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45-SML1695-25MG 25 mg
$435.00
1/EA
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assay ≥98% (HPLC)
color white
form film
Quality Level 100 
SMILES string O=C(N1)[C@@H](NC(NC2=CC=CC=C2F)=O)N=C(C3=CC=CC=C3)C4=C1C=CC=C4
solubility DMSO: 20 mg/mL, clear
storage condition protect from light
storage temp. 2-8°C
Biochem/physiol Actions: RSV604 (RSV-604) is a cell-permeable, non-cytotoxic (CC50 >50 μM) benzodiazepine derivative that is reported to target respiratory syncytial virus (RSV) nucleoprotein (N) via affinity interaction (Kd = 134 μM) and display similar antiviral potency against 40 clinical human RSV isolates (Ave. EC50 = 800 nM), including both subtypes A and B. Although RSV604 displays host-dependent potency against RSV cellular replication (EC50 = 2 μM/HeLa, 1.8 μM/HEp-2, >50 μM/BHK-21 based on cellular viral F protein level 72 hrs post RSV A2 infection) and release (by >1,000,000-fold/HeLa vs. no effect/BHK-21 72 hrs post infection; [RSV604] = EC90), complete loss of infectivity of released RSV from RSV604-treated cells is observed in both HeLa and BHK-21 cultures. RSV604 is also active against bovine RSV, but inactive toward mouse pneumonia virus, human metapneumovirus or parainfluenza virus types 1 &3 (PIV1 &PIV3).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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