RSV604
SIGMA/SML1695 - ≥98% (HPLC)
Synonym: (S)
CAS Number: 676128-63-5
Empirical Formula (Hill Notation): C22H17FN4O2
Molecular Weight: 388.39
MDL Number: MFCD28963952
Linear Formula: C22H17FN4O2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white |
| form | film |
| Quality Level | 100  |
| SMILES string | O=C(N1)[C@@H](NC(NC2=CC=C |
| solubility | DMSO: 20 mg/mL, clear |
| storage condition | protect from light |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | RSV604 (RSV-604) is a cell-permeable, non-cytotoxic (CC50 >50 μM) benzodiazepine derivative that is reported to target respiratory syncytial virus (RSV) nucleoprotein (N) via affinity interaction (Kd = 134 μM) and display similar antiviral potency against 40 clinical human RSV isolates (Ave. EC50 = 800 nM), including both subtypes A and B. Although RSV604 displays host-dependent potency against RSV cellular replication (EC50 = 2 μM/HeLa, 1.8 μM/HEp-2, >50 μM/BHK-21 based on cellular viral F protein level 72 hrs post RSV A2 infection) and release (by >1,000,000-fold/HeLa vs. no effect/BHK-21 72 hrs post infection; [RSV604] = EC90), complete loss of infectivity of released RSV from RSV604-treated cells is observed in both HeLa and BHK-21 cultures. RSV604 is also active against bovine RSV, but inactive toward mouse pneumonia virus, human metapneumovirus or parainfluenza virus types 1 &3 (PIV1 &PIV3). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |