OGG1 Inhibitor O8
SIGMA/SML1697 - ≥98% (HPLC)
Synonym: 3,4-
CAS Number: 350997-39-6
Empirical Formula (Hill Notation): C9H6Cl2N2OS
Molecular Weight: 261.13
MDL Number: MFCD01993639
Linear Formula: C9H6Cl2N2OS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C9H6Cl2N2OS/c10-4-2-1- |
InChI key | HSSHUDKWJRJKPV-UHFFFAOYSA |
Quality Level | 100 |
SMILES string | ClC1=C(C(NN)=O)SC2=CC=CC( |
solubility | DMSO: 5 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC50 value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate. |
General description: | Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |