OGG1 Inhibitor O8

SIGMA/SML1697 - ≥98% (HPLC)

Synonym: 3,4-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide

CAS Number: 350997-39-6
Empirical Formula (Hill Notation): C₉H₆Cl₂N₂OS
Molecular Weight: 261.13
MDL Number: MFCD01993639
Linear Formula: C₉H₆Cl₂N₂OS
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1697-5MG	5 mg	$108.00 1/EA		Add To Favorites
45-SML1697-25MG	25 mg	$435.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)
InChI key	HSSHUDKWJRJKPV-UHFFFAOYSA-N
Quality Level	100
SMILES string	ClC1=C(C(NN)=O)SC2=CC=CC(Cl)=C21
solubility	DMSO: 5 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	OGG1 Inhibitor O8 is a potent inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1), part of the DNA base excision repair (BER) pathway that is becoming a drug target for cancer therapy. OGG1 Inhibitor O8 has an IC₅₀ value of 220 nM and >100-fold selectivity for OGG1 relative to several other DNA repair glycosylases. O8 acts through the inhibition of Schiff base formation during OGG1 catalysis. It does not prevent DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.
General description:	Inhibition of 8-oxoguanine DNA glycosylase-1 (OGG1) can be used in monotherapy or in combination therapy to treat some types of cancer.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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