BX430

SIGMA/SML1701 - ≥98% (HPLC)

Synonym: N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N′-(3-pyridinyl)urea

CAS Number: 688309-70-8
Empirical Formula (Hill Notation): C₁₅H₁₅Br₂N₃O
Molecular Weight: 413.11
MDL Number: MFCD02678819
Linear Formula: C₁₅H₁₅Br₂N₃O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1701-5MG	5 mg	$86.10 1/EA	Add To Favorites
45-SML1701-25MG	25 mg	$348.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21)
InChI key	JFNKIJKRXKPQCC-UHFFFAOYSA-N
Quality Level	100
SMILES string	BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

BX430 is a selective noncompetitive allosteric antagonist of human P2X4 receptor channels. P2X4 receptors are highly expressed in the CNS, and have been studied as a therapeutic target for neuropathic pain and inflammation, and treatment of traumatic brain injury, cerebral ischemia, and spinal cord injury. BX430 is highly selective for human P2X4, with minimal activity towards other P2X subtypes, including P2X1–P2X3, P2X5, and P2X7. BX430 is also an antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 receptors. BX430 has an IC₅₀ value of 540 nM.

Packaging:

5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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