Synonym: (8S)-3,8-Bis[[(1,1-dimethylethoxy)carbonyl]amino]-9-oxo-2,4,10,17-tetraazaoctadec-3-enedioic acid 1-(1,1-dimethylethyl) 18-(phenylmethyl) ester
CAS Number: 1884710-81-9
Empirical Formula (Hill Notation): C35H58N6O9
Molecular Weight: 706.87
Linear Formula: C35H58N6O9
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O=C(OCC1=CC=CC=C1)NCCCCCCNC([C@H](CCCN/C(NC(OC(C)(C)C)=O)=NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O)=O |
solubility |
DMSO: 20 mg/mL, clear |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Cbz-B3A is a potent and selective inhibitor of mTORC1 signaling that inhibits the phosphorylation of eIF4E binding protein 1 (4EBP1) and blocks 68% of translation. Cbz-B3A binds to ubiquilins 1, 2, and 4, which prevents mTORC1 activation. |
Other Notes: |
Light and air sensitive. |
Packaging: |
5 mg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |