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JNJ-47965567

SIGMA/SML1708 - ≥98% (HPLC)

Synonym: 2-(Phenylthio)-N-[[tetrahydro-4-(4-phenyl-1-piperazinyl)-2H-pyran-4-yl]methyl]-3-pyridinecarboxamide

CAS Number: 1428327-31-4
Empirical Formula (Hill Notation): C28H32N4O2S
Molecular Weight: 488.64
MDL Number: MFCD28334214
Linear Formula: C28H32N4O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1708-5MG 5 mg
 $128.00
1/EA		 Add To Favorites
45-SML1708-25MG 25 mg
 $523.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=C(NCC1(CCOCC1)N2CCN(C3=CC=CC=C3)CC2)C4=CC=CN=C4SC5=CC=CC=C5
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: JNJ-47965567 is a potent P2X7 antagonist with high affinity for the rat receptor (pKi = 8.7). It is centrally available after systemic injection with a superior brain:plasma distribution compared to other available P2X7 antagonists. JNJ-47965567 was shown to suppress epileptic seizures in a mouse model of epilepsy. It appears to have a disease modifying effect since spontaneous seizure rates did not increase once treatment with JNJ-477965567 was stopped.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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