Talniflumate

SIGMA/SML1710 - ≥98% (HPLC)

Synonym: 2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid 1,3-dihydro-3-oxo-1-isobenzofuranyl ester

CAS Number: 66898-62-2
Empirical Formula (Hill Notation): C₂₁H₁₃F₃N₂O₄
Molecular Weight: 414.33
Linear Formula: C₂₁H₁₃F₃N₂O₄
Product Type: Chemical

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C21H13F3N2O4/c22-21(23,24)12-5-3-6-13(11-12)26-17-16(9-4-10-25-17)19(28)30-20-15-8-2-1-7-14(15)18(27)29-20/h1-11,20H,(H,25,26)
InChI key	ANMLJLFWUCQGKZ-UHFFFAOYSA-N
Quality Level	100
solubility	DMSO: 5 mg/mL, clear (warmed)
storage temp.	room temp

Biochem/physiol Actions:	Talniflumate is a phthalidyl ester of niflumic acid. It acts as an anti-inflammatory molecule and a mucoregulator. Talniflumate is used as a potent therapeutic for cystic fibrosis, chronic obstructive pulmonary disease and asthma. Talniflumate also inhibits the calcium-activated chloride channel hCLCA function, which is involved in mucus overproduction.
Biochem/physiol Actions:	Talniflumate is an orally available, potent and selective inhibitor of core mucin-synthesizing enzyme GCNT3 (core 2 b-1,6 N-acetylglucosaminyltransferase). Talniflumate decreases GCNT3 expression and production of mucins in vivo and in vitro. Talniflumate improves responsiveness of pancreatic tumors to gefitinib. Talniflumate is a potent calcium-activated chloride channel (CaCC) blocker.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable