TNCA
SIGMA/SML1711 - ≥98% (HPLC)
Synonym: (3S)
CAS Number: 42438-90-4
Empirical Formula (Hill Notation): C12H12N2O2
Molecular Weight: 216.24
MDL Number: MFCD00272641
Linear Formula: C12H12N2O2
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1711-10MG.
This image depicts SML1711-10MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C12H12N2O2/c15-12(16)1 |
| InChI key | FSNCEEGOMTYXKY-JTQLQIEISA |
| optical activity | [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1)) |
| Quality Level | 100  |
| SMILES string | O=C(O)[C@H]1NCC2=C(C3=C(N |
| solubility | 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed) |
| storage temp. | −20°C |
| Biochem/physiol Actions: | TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. |
| Biochem/physiol Actions: | TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist. |
| Packaging: | 10, 50 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |