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SBC-115076

SIGMA/SML1712 - ≥98% (HPLC)

Synonym: 1,5-Dihydro-3-hydroxy-4-[3-methyl-4-(phenylmethoxy)benzoyl]-1-[3-(4-morpholinyl)propyl]-5-(4-pyridinyl)-2H-pyrrol-2-one

CAS Number: 489415-96-5
Empirical Formula (Hill Notation): C31H33N3O5
Molecular Weight: 527.61
MDL Number: MFCD03296540
Linear Formula: C31H33N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1712-5MG 5 mg
 $144.00
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assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string CC1=CC(C(C(C(C2=CC=NC=C2)N3CCCN4CCOCC4)=C(O)C3=O)=O)=CC=C1OCC5=CC=CC=C5
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: SBC-115076 is an inhibitor of PCSK9 (proprotein convertase subtilisin-kexin 9). PCSK9 binds to the LDL receptor, preventing it from removing LDL cholesterol from the blood. SBC-115076 was shown to inihbit PCSK9, blocking LDLR degradation in HEK293T cells expressing PCSK9 and to increase the uptake of LDL by liver cells in vitro. SBC-115076 lowered cholesterol levels in mice fed a high fat diet.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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