MSAB
SIGMA/SML1726 - ≥95% (HPLC)
Synonym: 3-
CAS Number: 173436-66-3
Empirical Formula (Hill Notation): C15H15NO4S
Molecular Weight: 305.35
Linear Formula: C15H15NO4S
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | off-white to purple |
| form | powder |
| Quality Level | 100  |
| SMILES string | CC1=CC=C(S(NC2=CC(C(OC)=O |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | A cell-permeable compound that targets β-catenin via direct affinity interaction within the C-terminal two thirds (a.a. 301-670) of the Armadillo repeat region (a.a. 136–686), inducing β-catenin ubiquitination and proteasomal degradation (Eff. conc. 1.25-5 μM in DLD-1, SW480 and LS174T cultures). MSAB selectively inhibits against Wnt sginaling-dependent proliferation of cancer cells (IC50 <6 μM), while exhibiting little efficacy in Wnt-independent cultures (<10% inhibition at 10 μM). Likewise, daily intraperitoneal injection (10-20 mg/kg/day) is efficacious in suppressing the expansion of established tumors from HCT116, HT115, and H23 xenografts in mice, while exhibiting little efficacy against the Wnt-independent H460 tumor growth. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |