LP117
SIGMA/SML1730 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 1056468-55-3
Empirical Formula (Hill Notation): C21H23ClN4O2S
Molecular Weight: 430.95
Linear Formula: C21H23ClN4O2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | ClC1=NC(SC(C(OCC)=O)CCCC) |
solubility | DMSO: 25 mg/mL, clear |
storage condition | protect from light |
storage temp. | 2-8°C |
Biochem/physiol Actions: | LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. LP117 effectively reduces drug-resistance in ABCB1-expressing neuroblastoma cultures while exhibiting no efficacy toward non-ABCB1 substrate cisplatin or in non-ABCB1-expressing cancer cultures. |
Packaging: | 5, 25 mg in glass bottle |
Hazard statements | H413 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |