LP117

SIGMA/SML1730 - ≥98% (HPLC)

Synonym: 2-[[4-Chloro-6-(6-quinolinylamino)-2-pyrimidinyl]thio]-hexanoic acid ethyl ester; Ethyl 2-((4-chloro-6-(quinolin-6-ylamino)pyrimidin-2-yl)thio)hexanoate

CAS Number: 1056468-55-3
Empirical Formula (Hill Notation): C₂₁H₂₃ClN₄O₂S
Molecular Weight: 430.95
Linear Formula: C₂₁H₂₃ClN₄O₂S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1730-5MG	5 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites
45-SML1730-25MG	25 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	ClC1=NC(SC(C(OCC)=O)CCCC)=NC(NC2=CC3=C(C=C2)N=CC=C3)=C1
solubility	DMSO: 25 mg/mL, clear
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:

LP117 is a pirinixic acid derivative that interferes with ATP-binding cassette (ABC) transporter ABCB1-mediated substrates transport, including vincristine, vinorelbine, paclitaxel, and actinomycin D, but not doxorubicin, rhodamine 123, or JC-1. LP117 effectively reduces drug-resistance in ABCB1-expressing neuroblastoma cultures while exhibiting no efficacy toward non-ABCB1 substrate cisplatin or in non-ABCB1-expressing cancer cultures.

Packaging:

5, 25 mg in glass bottle

Hazard statements	H413
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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