FINDY
SIGMA/SML1733 - ≥98% (HPLC)
Synonym: (5Z)
CAS Number: 1507367-37-4
Empirical Formula (Hill Notation): C16H17NO2S2Si
Molecular Weight: 347.53
Linear Formula: C16H17NO2S2Si
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | light yellow to dark yellow |
| form | powder |
| Quality Level | 100  |
| SMILES string | C[Si](C)(C)C#CC1=C(OC)C=C |
| solubility | DMSO: 25 mg/mL, clear |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | FINDY is a cell-permeable thioxothiazolidinone derivative that specifically targets newly synthesized cellular DYRK1A, but not DYRK1B or DYRK2, for proteasomal degradation by suppressing DYKR1A intramolecular Ser97 autophosphorylation, a necessary event for folding/maturation of newly translated DYRK1A. Unlike INDY and other ATP-competitive DYRK inhibitors, FINDY is ineffective against the kinase activity of DYRK1A, DYRK1B, DYRK2, or DYRK3 (IC50 >10 μM) and inhibits only five kinases (GSK3β, MARK4, PIM1, PIM3, PLK3) by over 75% at 10 μM among a panel of 271 other kinases. FINDY (2.5 μM) is shown to selectively rescue the developmental defect of Xenopus embryos induced by the overexpression of DYRK1A, but not DYRK1B, while INDY prodrug (2.5 μM) treatment indiscriminately prevents defect caused by both DYRK1A and DYRK1B expression. |
| Biochem/physiol Actions: | FINDY is a structural analog of RD0392, a canonical ATP-competitive inhibitor of mature dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |