Nelarabine
SIGMA/SML1736 - ≥98% (HPLC)
Synonym: 2-amino-9-β-D-arabinofuranosyl-6-methoxy-9H-purine; 506U; 506U78; 9-β-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine; Arranon; Atriance; GW-506U78
CAS Number: 121032-29-9
Empirical Formula (Hill Notation): C11H15N5O5
Molecular Weight: 297.27
Linear Formula: C11H15N5O5
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C11H15N5O5/c1-20-9-5-8 |
InChI key | IXOXBSCIXZEQEQ-KBNQYOMWSA |
Quality Level | 100 ![]() |
SMILES string | O[C@@H]1[C@@H](O[C@H](CO) |
solubility | H2O: 5 mg/mL, clear (warmed) |
storage condition | desiccated |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Nelarabine is an antineoplastic purine nucleoside analog used in T-cell acute lymphoblastic leukemia. It is a pro-drug of Ara-G, which is converted by cellular kinases to the active 5′-triphosphate, Ara-GTP. Incorporation of Ara-GTP into DNA leads to inhibition of DNA synthesis and apoptosis. |
Packaging: | 10, 50 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |