FIN56
SIGMA/SML1740 - ≥98% (HPLC)
Synonym: N2,N7-
CAS Number: 1083162-61-1
Empirical Formula (Hill Notation): C25H31N3O5S2
Molecular Weight: 517.66
Linear Formula: C25H31N3O5S2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C25H31N3O5S2/c29-26-25 |
| InChI key | OYLSCKVHQYAZEE-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [S](=O)(=O)(NC5CCCCC5)c1c |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | room temp |
| Biochem/physiol Actions: | Ferroptosis inducer 56 (FIN56) is a member of the class 3 ferroptosis inducers. |
| Biochem/physiol Actions: | FIN56 is a specific inducer of ferroptosis, a non-apoptotic form of cell death characterized by iron-dependent accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS). FIN56 has an EC50 value of 240 nM, and is believed to act though two separate pathways. The first requires the enzymatic activity of acetyl-CoA carboxylase (ACC),and results in degradation of glutathione peroxidase 4 (GPX4), which acts as a negative regulator of ferroptosis by reducing lipid hydroperoxides. The second pathway involves FIN56 binding to and activing squalene synthase, which leads to coenzyme Q10 depletion. |
| Biochem/physiol Actions: | FIN56 is a specific inducer of ferroptosis. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |