A-971432
SIGMA/SML1744 - ≥95% (HPLC)
Synonym: 1-
CAS Number: 1240308-45-5
Empirical Formula (Hill Notation): C18H17Cl2NO3
Molecular Weight: 366.24
MDL Number: MFCD30182357
Linear Formula: C18H17Cl2NO3
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C18H17Cl2NO3/c19-16-6- |
| InChI key | WAAWETUDFSIYSD-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | ClC1=CC(COC2=CC=C(CN3CC(C |
| solubility | DMSO: 3 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50 = 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50 >10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t1/2 = 5.7 h; Cmax = 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg. |
| Biochem/physiol Actions: | A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |