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Raptinal

SIGMA/SML1745 - ≥95% (HPLC)

Synonym: 9H,9′H-9,9′-Bifluorene-9,9′-dicarbaldehyde

CAS Number: 1176-09-6
Empirical Formula (Hill Notation): C28H18O2
Molecular Weight: 386.44
Linear Formula: C28H18O2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-SML1745-5MG 5 mg
$114.00
1/EA
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45-SML1745-25MG 25 mg
$464.00
1/EA
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assay ≥95% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string O=CC(C1=C2C=CC=C1)(C3(C=O)C4=C(C5=C3C=CC=C5)C=CC=C4)C6=C2C=CC=C6
solubility DMSO: 5 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Raptinal showed complete cytochrome c release within 30 minutes and caspase-3 activation within one hour of exposure (10 μM). Despite its general cytotoxicity in both cancer and non-cancer cell cultures (Cell death induction EC50 = 0.6-3.4 μM in 24 hr), no hematologic toxicity was observed 7 days following single 60 mg/kg i.v. dosing in mice. Studies show that daily i.p. injection (20 mg/kg) is efficacious in suppressing murine B16-F10 melanoma and 4T1 breast cancer expansion in vivo (by ~60% and 50% in 6 days, respectively).
Biochem/physiol Actions: Raptinal is a cell-permeable bifluorene-dicarbaldehyde compound that acts as a rapid activator of mitochondrial pathway-mediated intrinsic apoptosis.
Packaging: 5 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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