JNJ-55511118

SIGMA/SML1747 - ≥98% (HPLC)

Synonym: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one

Empirical Formula (Hill Notation): C₁₄H₈ClF₃N₂O₂
Molecular Weight: 328.67
Linear Formula: C₁₄H₈ClF₃N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1747-5MG	5 mg	$128.00 1/EA		Add To Favorites
45-SML1747-25MG	25 mg	$523.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
solubility	DMSO: 25 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:	JNJ-55511118 is also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one. It acts as an anticonvulsant or neuroprotectant. It is considered as a reversible α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibitor, mainly in the hippocampus region.
Biochem/physiol Actions:	JNJ-55511118 is an orally available, brain penetrant, potent and selective negative modulator of AMPA receptors that requires the presence of the accessory protein CACNG8 (TARP-γ8). JNJ-55511118 exhibit potent inhibition of neurotransmission within hippocampus, and a strong anti-convulsant effect.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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