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JNJ-55511118

SIGMA/SML1747 - ≥98% (HPLC)

Synonym: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one

Empirical Formula (Hill Notation): C14H8ClF3N2O2
Molecular Weight: 328.67
Linear Formula: C14H8ClF3N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1747-5MG 5 mg
 $120.00
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45-SML1747-25MG 25 mg
 $490.00
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This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
solubility DMSO: 25 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: JNJ-55511118 is also known as 5-[2-chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydrobenzimidazol-2-one. It acts as an anticonvulsant or neuroprotectant. It is considered as a reversible α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor inhibitor, mainly in the hippocampus region.
Biochem/physiol Actions: JNJ-55511118 is an orally available, brain penetrant, potent and selective negative modulator of AMPA receptors that requires the presence of the accessory protein CACNG8 (TARP-γ8). JNJ-55511118 exhibit potent inhibition of neurotransmission within hippocampus, and a strong anti-convulsant effect.
Biochem/physiol Actions: JNJ-55511118 is an orally available, brain penetrant, potent and selective negative modulator of AMPA receptors.
Packaging: 5, 25 mg in glass bottle
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H315 - H319 - H335
Precautionary statements P305 + P351 + P338
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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