Narasin Ready Made Solution

SIGMA/SML1749 - 1 mg/ml in DMSO

Synonym: (2R)-2-[(2R,3S,5S,6R)-6-[(2S,3S,4S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5^{7}.3^{5}]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-3,5-dimethyloxan-2-yl]butanoic acid; (4S)-4-Methylsalinomycin; A 28086A; Antibiotic A 28086A; Antibiotic C 7819B; C 7819B; Monteban; Narasin A; Narasul

CAS Number: 55134-13-9
Empirical Formula (Hill Notation): C₄₃H₇₂O₁₁
Molecular Weight: 765.03
Linear Formula: C₄₃H₇₂O₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1749-1ML	1 mL	$161.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

biological source	Streptomyces aureofaciens
concentration	1 mg/ml in DMSO
form	solution
InChI	1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)/t23-,24-,25-,26+,27-,28-,29-,30-,31+,32+,33+,34+,36+,37+,38-,40-,41+,42-,43-/m0/s1
InChI key	VHKXXVVRRDYCIK-CWCPJSEDSA-N
Quality Level	200
shipped in	dry ice
SMILES string	O1[C@H]([C@H](C[C@@H]([C@@H]1[C@@H](CC)C(=O)O)C)C)[C@H]([C@H](O)[C@H](C)C(=O)[C@@H]([C@H]2O[C@@]3(O[C@]4(O[C@@](CC4)([C@@H]5O[C@H]([C@@](CC5)(O)CC)C)C)[C@@H](C=C3)O)[C@@H](C[C@@H]2C)C)CC)C
storage temp.	−20°C

Biochem/physiol Actions:	Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. Narasin inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.
Biochem/physiol Actions:	Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. Narasin inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange. In addition, Narasin inhibits Dengue virus (DENV) at the post-entry stage of viral replication during DENV infection. The inhibition of DENV involves a non-cytotoxic mechanism, therefore, Narasin can be possibly considered as therapeutic agent against DENV infection. A dose dependent curve (0.01-5 μM) showed that Narasin has 50% inhibitory concentration at less than 1 μM against all four serotypes of DENV. The IC₅₀ (μM) of Narasin against four different DENV serotypes was 0.05-0.65 μM.
Other Notes:	Narasin solution is provided at 1.307 mM (1 mg/ml). Typical final concentration for use in cell culture is 0.01-5 μM. Stable at –20 °C for at least 2 years.

WGK Germany	WGK 1
Flash Point(F)	188.6 °F - closed cup
Flash Point(C)	87 °C - closed cup

Storage Temp.	−20°C
UNSPSC	12352200

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