Fidaxomicin
SIGMA/SML1750 - ≥95% (HPLC)
Synonym: Clostomicin B1; Lipiarmycin A3; OPT 80; Tiacumicin B
CAS Number: 873857-62-6
Empirical Formula (Hill Notation): C52H74Cl2O18
Molecular Weight: 1058.04
MDL Number: MFCD27976367
Linear Formula: C52H74Cl2O18
Product Type: Chemical
assay | ≥95% (HPLC) |
biological source | (Actinoplanes deccanensis) |
form | powder |
Quality Level | 200 ![]() |
shipped in | ambient |
SMILES string | ClC1=C(CC)C(C(O[C@H]2[C@H |
solubility | chloroform: soluble 10 mg/mL |
DMSO: soluble 1 mg/mL | |
methanol: soluble 10 mg/mL | |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Fidaxomicin is a first-in-class macrocyclic antibacterial agent for gram positive bacteria treatment, notably Clostridium difficile infections. Fidaxomicin produces its antibacterial effects by inhibiting bacterial RNA polymerase at transcription initiation. Furthermore, Fidaxomicin is an inhibitor of bacterial transcription. Fidaxomicin acts at an earlier step in the transcription initiation pathway. Specifically, Fidaxomicin binds to the DNA template-RNA polymerase complex and prevents the initial separation of DNA strands, which precedes messenger RNA synthesis by inhibiting the s subunit. Fidaxomicin′s unique target site may explain its limited spectrum of antimicrobial activity because s subunits differ among bacterial species. |
Biochem/physiol Actions: | Therapeutic dosage of fidaxomicin is found have less bactericidal effect on the bowel microbiota and reduces the recurrence of C. difficile infection. |
Other Notes: | Chemical name: [(2R,3S,4S,5S,6R)-6-[[(3E |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |