GSK591
SIGMA/SML1751 - ≥97% (HPLC)
Synonym: 2-
CAS Number: 1616391-87-7
Empirical Formula (Hill Notation): C22H28N4O2
Molecular Weight: 380.48
MDL Number: MFCD30187524
Linear Formula: C22H28N4O2
Product Type: Chemical
assay | ≥97% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(NC[C@H](O)CN1CCC(C=CC |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | GSK591 is a SGC probe for PRMT5. GSK591 is a potent and selective inhibitor of H4 histone methylation by PRMT5/MEP50 complex. For full characterization details, please visit the GSK591 probe summary ![]() ![]() SGC2096 is the negative control for the active probe, GSK-591. To request a sample of the negative control from the SGC, click here ![]() ![]() To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc ![]() |
Biochem/physiol Actions: | GSK591 is also known as 2-(cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydrox |
Features and Benefits: | GSK591 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC ![]() |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here ![]() ![]() |
Other Notes: | GSK591 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK591 probe summary ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥97% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |