GSK864
SIGMA/SML1757 - ≥98% (HPLC)
Synonym: (S)
CAS Number: 1816331-66-4
Empirical Formula (Hill Notation): C30H31FN6O4
Molecular Weight: 558.60
Linear Formula: C30H31FN6O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
optical activity | [α]/D -66 to -76°, c = 0.5 in methanol |
Quality Level | 100 ![]() |
SMILES string | O=C(C1=CC=CN1)N2C[C@@](C( |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | GSK864 helps to decrease cell viability and stimulates apoptosis of tumor cells. |
Biochem/physiol Actions: | GSK864 is a cell penetrant, potent and selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) that potently inhibits intracellular 2-hydroxyglutarate (2-HG) production in HT-1080 cells. It appears that GSK864 binds to an allosteric binding site and locks WT and mutant IDH1s in a catalytically inactive conformation. GSK864 is a highly bioavailable analog of GSK321. For full characterization details, please visit the GSK864 probe summary ![]() ![]() To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc ![]() |
Features and Benefits: | GSK864 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC ![]() |
Features and Benefits: | This compound is a featured product for Nitric Oxide & Cell Stress research. Click here ![]() ![]() |
Other Notes: | GSK864 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK864 probe summary ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |