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GSK864

SIGMA/SML1757 - ≥98% (HPLC)

Synonym: (S)-1-(4-Fluorobenzyl)-N3-(4-methoxy-3,5-dimethylphenyl)-7-methyl-5-(1H-pyrrole-2-carbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3,7-dicarboxamide

CAS Number: 1816331-66-4
Empirical Formula (Hill Notation): C30H31FN6O4
Molecular Weight: 558.60
Linear Formula: C30H31FN6O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1757-5MG 5 mg
 $334.00
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45-SML1757-25MG 25 mg
 $1290.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
optical activity [α]/D -66 to -76°, c = 0.5 in methanol
Quality Level 100 
SMILES string O=C(C1=CC=CN1)N2C[C@@](C(N)=O)(C)C(N(CC3=CC=C(F)C=C3)N=C4C(NC5=CC(C)=C(OC)C(C)=C5)=O)=C4C2
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: GSK864 helps to decrease cell viability and stimulates apoptosis of tumor cells.
Biochem/physiol Actions: GSK864 is a cell penetrant, potent and selective allosteric inhibitor of isocitrate dehydrogenase 1 (IDH1) that potently inhibits intracellular 2-hydroxyglutarate (2-HG) production in HT-1080 cells. It appears that GSK864 binds to an allosteric binding site and locks WT and mutant IDH1s in a catalytically inactive conformation. GSK864 is a highly bioavailable analog of GSK321. For full characterization details, please visit the GSK864 probe summary  on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc 
Features and Benefits: GSK864 is a chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC chemical probes, visit sigma.com/SGC .
Features and Benefits: This compound is a featured product for Nitric Oxide & Cell Stress research. Click here  to discover more featured Nitric Oxide & Cell Stress products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Other Notes: GSK864 has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the GSK864 probe summary  on the Chemical Probes Portal website.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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