Synonym: BAM 15; N5,N6-bis(2-Fluorophenyl)[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine
CAS Number: 210302-17-3
Empirical Formula (Hill Notation): C16H10F2N6O
Molecular Weight: 340.29
MDL Number: MFCD00373912
Linear Formula: C16H10F2N6O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| InChI |
1S/C16H10F2N6O/c17-9-5-1-3-7-11(9)19-13-14(20-12-8-4-2-6-10(12)18)22-16-15(21-13)23-25-24-16/h1-8H,(H,19,21,23)(H,20,22,24) |
| InChI key |
OEGJBRZAJRPPHL-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
FC(C=CC=C1)=C1NC2=NC3=NON=C3N=C2NC4=CC=CC=C4F |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
BAM15 increases mitochondrial respiration rate and is also found to be less cytotoxic compared to other protonophore uncouplers such as carbonyl cyanide p-trifluoromethoxyphenylhydrazone. Hindered oncogenic MAPK (mitogen-activated protein kinase ) signaling leads to BAM15 induced mitochondrial apoptotic pathway activation. |
| Biochem/physiol Actions: |
BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria that that does not depolarizes the plasma membrane. BAM15 protects mice from acute renal ischemic-reperfusion injury. |
| Biochem/physiol Actions: |
BAM15 is a cell penetrant and potent uncoupler of oxidative phosphorylation in mitochondria. |
| Packaging: |
5, 25 mg in glass bottle |
| Hazard statements |
H413 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
