Cyclotraxin-B trifluoroacetate salt
SIGMA/SML1769 - ≥95% (HPLC)
Synonym: CNPMGYTKEGC (Modifications: Disulfide bridge between 1 - 11); L-
CAS Number: 1203586-72-4 (free base)
Empirical Formula (Hill Notation): C48H73N13O17S3 · xC2HF3O2
Molecular Weight: 1200.37 (free base basis)
Linear Formula: C48H73N13O17S3 · xC2HF3O2
Product Type: Chemical
assay | ≥95% (HPLC) |
color | colorless |
form | film |
InChI | 1S/C48H73N13O17S3/c1-24(6 |
InChI key | JLBMMJHZUYBFGX-ZHTCEXBHSA |
Quality Level | 100 |
shipped in | wet ice |
storage temp. | −20°C |
Biochem/physiol Actions: | Cyclotraxin-B is a potent and selective Trk B (BDNF/NT-3) receptor inhibitor. Cyclotraxin-B prevents receptor activation by BDNF without interfering with BDNF binding. Cyclotraxin-B has an IC50 value < 1 nM. In rodent studies Cyclotraxin-B, sometimes fused with tat-protein for increased brain permeability, has been shown to have anxiolytic properties, prevent cold hypersensitivity induced by BDNF, and to reduce cocaine self-administration. |
Packaging: | 1 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |