Givinostat hydrochloride hydrate
SIGMA/SML1772 - ≥95% (HPLC)
Synonym: Diethyl-
CAS Number: 732302-99-7
Empirical Formula (Hill Notation): C24H27N3O4 · HCl · H2O
Molecular Weight: 475.97
MDL Number: MFCD18385007
Linear Formula: C24H27N3O4 · HCl · H2O
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| SMILES string | [H]Cl.[H]O[H].CCN(CC)CC1= |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Application: | Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4+ T-cell model. |
| Biochem/physiol Actions: | Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas). |
| Biochem/physiol Actions: | Givinostat is known to mediate the reduction of the human immunodeficiency virus release in macrophages. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |