Givinostat hydrochloride hydrate
SIGMA/SML1772 - ≥95% (HPLC)
Synonym: Diethyl-
CAS Number: 732302-99-7
Empirical Formula (Hill Notation): C24H27N3O4 · HCl · H2O
Molecular Weight: 475.97
MDL Number: MFCD18385007
Linear Formula: C24H27N3O4 · HCl · H2O
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1772-5MG.
This image depicts SML1772-5MG.
| assay | ≥95% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C24H27N3O4.ClH.H2O/c1- |
| InChI key | FKGKZBBDJSKCIS-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [H]Cl.[H]O[H].CCN(CC)CC1= |
| solubility | DMSO: 20 mg/mL, clear |
| storage condition | desiccated |
| storage temp. | −20°C |
| Application: | Givinostat hydrochloride hydrate has been used as a histone deacetylase inhibitor to test its effect on the human immunodeficiency virus reactivation in CD4+ T-cell model. |
| Biochem/physiol Actions: | Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. |
| Biochem/physiol Actions: | Givinostat (ITF2357) is a hydroxamate HDAC inhibitor that inhibits class I and class II enzymes. Givinostat posseses a very promising activity profile in multiple myeloma and acute myelogenous leukemia in vitro and in vivo. Givinostat also has anti-inflammatory activity and inhibits the secretion of the tumor necrosis factor-alpha (TNF-α), IL-1, and IL-6. Givinostat has been in multiple Phase 2 studies for both inflammatory diseases (Duchenne Muscular Dystrophy , Juvenile arthritis, Polycythemia Vera) and blood cancers (myelomas and lymphomas). |
| Biochem/physiol Actions: | Givinostat is known to mediate the reduction of the human immunodeficiency virus release in macrophages. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |