SR0987
SIGMA/SML1778 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 303126-97-8
Empirical Formula (Hill Notation): C16H10ClF6NO2
Molecular Weight: 397.70
Linear Formula: C16H10ClF6NO2
Product Type: Chemical
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| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI key | IZVBONMVWLTLNT-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | FC(F)(F)C(O)(C(F)(F)F)c1c |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency toward T-cell-specific retinoic acid receptor-related orphan receptor ROR?t (EC50 ~800 nM in cell-based reporter assays) by targeting an allosteric pocket within the RORγt ligand-binding domain (LBD). In addition to upregulating RORγt target gene IL17A expression, SR0987 is shown to simultaneously downregulate surface immune checkpoint protein PD-1 expression by a yet unidentified mechanism among ex vivo differentiated murine TH17 cells, as well as PMA/ionophore-stimulated human Jurkat T cells and murine EL4 T lymphocytes. |
| Biochem/physiol Actions: | SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H302 - H410 |
| Precautionary statements | P301 + P312 + P330 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |