Synonym: 2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propanyl)phenyl)benzamide
CAS Number: 303126-97-8
Empirical Formula (Hill Notation): C16H10ClF6NO2
Molecular Weight: 397.70
Linear Formula: C16H10ClF6NO2
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to beige |
| form |
powder |
| Quality Level |
100  |
| solubility |
DMSO: 20 mg/mL, clear |
| storage temp. |
−20°C |
| Biochem/physiol Actions: |
SR0987 is a cell-permeable SR1078 analog with ~6-fold improved agonist potency toward T-cell-specific retinoic acid receptor-related orphan receptor ROR?t (EC50 ~800 nM in cell-based reporter assays) by targeting an allosteric pocket within the RORγt ligand-binding domain (LBD). In addition to upregulating RORγt target gene IL17A expression, SR0987 is shown to simultaneously downregulate surface immune checkpoint protein PD-1 expression by a yet unidentified mechanism among ex vivo differentiated murine TH17 cells, as well as PMA/ionophore-stimulated human Jurkat T cells and murine EL4 T lymphocytes. |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
  GHS07,GHS09 |
| Signal word |
Warning |
| Hazard statements |
H302 - H410 |
| Precautionary statements |
P301 + P312 + P330 |
| RIDADR |
UN 3077 9 / PGIII |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
