Nigericin sodium salt Ready Made Solution
SIGMA/SML1779 - 5 mg/mL (DMSO:ethanol 1:1)
Synonym: 3B2-6379; Antibiotic K178; Antibiotic X464; Azalomycin M; HE331800; Helexin C; Polyetherin A; sodium;2-
CAS Number: 28643-80-3
Empirical Formula (Hill Notation): C40H67NaO11
Molecular Weight: 746.94
Linear Formula: C40H67NaO11
Product Type: Chemical
antibiotic activity spectrum | Gram-positive bacteria |
biological source | Streptomyces hygroscopicus |
concentration | 5 mg/mL (DMSO:ethanol 1:1) |
form | solution |
InChI | 1S/C40H68O11.Na/c1-21-11- |
InChI key | MOYOTUKECQMGHE-KKCUGXASSA |
mode of action | cell membrane | interferes |
Quality Level | 200 ![]() |
shipped in | ambient |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). Nigericin transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na+ and thus, disrupts membrane potential and stimulates ATPase activity in mitochondria. Nigericin kills bacteria by facilitating the diffusion of ions across membranes. Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus. Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems. |
Preparation Note: | Nigericin sodium salt ready made solution is provided at 6.7 mM concentration. The solution can be further diluted with a desired solvent to a working concentration (0.5-10 μM). |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H226 |
Precautionary statements | P210 - P233 - P240 - P241 - P242 - P243 |
RIDADR | UN1170 - class 3 - PG 3 - Ethanol, solution |
WGK Germany | WGK 2 |
Flash Point(F) | 78.8 °F |
Flash Point(C) | 26 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |