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Nigericin sodium salt Ready Made Solution

SIGMA/SML1779 - 5 mg/mL (DMSO:ethanol 1:1)

Synonym: 3B2-6379; Antibiotic K178; Antibiotic X464; Azalomycin M; HE331800; Helexin C; Polyetherin A; sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate

CAS Number: 28643-80-3
Empirical Formula (Hill Notation): C40H67NaO11
Molecular Weight: 746.94
Linear Formula: C40H67NaO11
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1779-1ML 1 mL
 $150.00
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antibiotic activity spectrum Gram-positive bacteria
biological source Streptomyces hygroscopicus
concentration 5 mg/mL (DMSO:ethanol 1:1)
form solution
InChI 1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key MOYOTUKECQMGHE-KKCUGXASSA-M
mode of action cell membrane | interferes
Quality Level 200 
shipped in ambient
storage temp. 2-8°C
Biochem/physiol Actions: Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K+) for H+ (antiport). Nigericin transports monovalent cations across membranes with the following specificity: K+ >Rb+ >Cs+ >>Na+ and thus, disrupts membrane potential and stimulates ATPase activity in mitochondria.
Nigericin kills bacteria by facilitating the diffusion of ions across membranes.
Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus. Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems.
Preparation Note: Nigericin sodium salt ready made solution is provided at 6.7 mM concentration. The solution can be further diluted with a desired solvent to a working concentration (0.5-10 μM).
Symbol GHS02  GHS02
Signal word Warning
Hazard statements H226
Precautionary statements P210 - P233 - P240 - P241 - P242 - P243
RIDADR UN1170 - class 3 - PG 3 - Ethanol, solution
WGK Germany WGK 2
Flash Point(F) 78.8 °F
Flash Point(C) 26 °C
Storage Temp. 2-8°C
UNSPSC 12352200

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