Nigericin sodium salt Ready Made Solution

SIGMA/SML1779 - 5 mg/mL (DMSO:ethanol 1:1)

Synonym: 3B2-6379; Antibiotic K178; Antibiotic X464; Azalomycin M; HE331800; Helexin C; Polyetherin A; sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate

CAS Number: 28643-80-3
Empirical Formula (Hill Notation): C₄₀H₆₇NaO₁₁
Molecular Weight: 746.94
Linear Formula: C₄₀H₆₇NaO₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1779-1ML	1 mL	$165.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-positive bacteria
biological source	Streptomyces hygroscopicus
concentration	5 mg/mL (DMSO:ethanol 1:1)
form	solution
InChI	1S/C40H68O11.Na/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34;/h21-35,41,44H,11-20H2,1-10H3,(H,42,43);/q;+1/p-1/t21-,22-,23-,24+,25?,26?,27+,28+,29+,30+,31+,32?,33?,34-,35?,37?,38?,39-,40+;/m0./s1
InChI key	MOYOTUKECQMGHE-KKCUGXASSA-M
mode of action	cell membrane \| interferes
Quality Level	200
shipped in	ambient
SMILES string	[Na+].[O-]C(=O)C(C1O[C@H](CC[C@@H]1C)C[C@H]2O[C@]3(OC(CC3C)(C4OC(CC4)(C5O[C@H](C[C@@H]5C)[C@H]6O[C@@]([C@@H](C[C@@H]6C)C)(O)CO)C)C)[C@@H]([C@@H](C2)OC)C)C
storage temp.	2-8°C

Biochem/physiol Actions:	Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K⁺) for H⁺ (antiport).
Biochem/physiol Actions:	Nigericin is a polyether ionophore which catalyzes the electroneutral exchange of alkali metal (K⁺) for H⁺ (antiport). Nigericin transports monovalent cations across membranes with the following specificity: K⁺ >Rb⁺>Cs⁺ >>Na⁺ and thus, disrupts membrane potential and stimulates ATPase activity in mitochondria. Nigericin kills bacteria by facilitating the diffusion of ions across membranes. Low concentration (0.5 μM) of Nigericin rapidly decreases pHi, causing stimulation of PG production 1.5- to 2-fold in cerebral microvascular endothelial cells and arresting of DNA synthesis in Erlich acites carcinoma cells. Treatment of Hela cells, after entry of poliovirus, with nigericin, prevents the inhibition of host protein synthesis by poliovirus.Nigericin is also widely used in studies of the consequences of changes in membrane potential in variable systems.
Preparation Note:	Nigericin sodium salt ready made solution is provided at 6.7 mM concentration. The solution can be further diluted with a desired solvent to a working concentration (0.5-10 μM).
Preparation Note:	The product can be stored at 2-8°C and is released with a 4 years suggested retest schedule. The solution is quite stable refrigerated and freezing is not necessary.
Preparation Note:	This product is a 5 mg/mL solution prepared in a 1:1 mixture of DMSO and Ethanol.

Symbol	GHS02
Signal word	Warning
Hazard statements	H226
Precautionary statements	P210 - P233 - P240 - P241 - P242 - P243
RIDADR	UN1170 - class 3 - PG 3 - Ethanol, solution
WGK Germany	WGK 2
Flash Point(F)	78.8 °F
Flash Point(C)	26 °C

Storage Temp.	2-8°C
UNSPSC	12352200

To Order From a Quote