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Sinensetin

SIGMA/SML1787 - ≥98% (HPLC)

Synonym: 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one; 2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxychromen-4-one; 3′,4′,5,6,7-Pentamethoxyflavone; 6-Hydroxyluteolin 5,6,7,3′,4′-pentamethyl ether; Pedalitin permethyl ether

CAS Number: 2306-27-6
Empirical Formula (Hill Notation): C20H20O7
Molecular Weight: 372.37
Linear Formula: C20H20O7
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1787-5MG 5 mg
 $125.00
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45-SML1787-25MG 25 mg
 $511.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1787-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3
InChI key LKMNXYDUQXAUCZ-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C1C=C(C2=CC(OC)=C(OC)C=C2)OC3=C1C(OC)=C(OC)C(OC)=C3
solubility DMSO: 3 mg/mL, clear (warmed)
storage temp. 2-8°C
Application: Sinensetin may be used as a citrus flavonoid to study its anti-adipogenic effects on AMP-activated protein kinase (AMPK) activation in palmitate (PA)-treated HepG2 cells. It may also be used as a standard to quantify polyphenol content in Orthosiphon stamineus extracts using ultra-performance liquid chromatography (UPLC).
Biochem/physiol Actions: Sinensetin is a citrus flavonoid with anti-inflammatory and anti-proliferative activity. It has also been shown to enhance adipogenesis and lipolysis. It exhibits anticancer, antimicrobial, anti-dementia, antioxidant, anti-obesity, anti-trypanosomal, and vasorelaxant activities. It is capable of inhibiting P-glycoprotein (P-gp), efflux transporter, and breast cancer resistance protein (BCRP). Sinensetin has the potential to serve as a flavonoid chemosensitizer.
General description: Sinensetin is a polymethoxylated flavonoid derived from plants. It is mainly seen in Orthosiphon aristatus var. aristatus and various citrus fruits. Sinensetin is abundantly present in the peel than in other parts of the citrus fruits.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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