Synonym: N-[2-[[[4-[2-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]amino]carbonyl]-4,5-dimethoxyphenyl]-3-quinolinecarboxamide; XR 9576; XR9576
CAS Number: 206873-63-4
Empirical Formula (Hill Notation): C38H38N4O6
Molecular Weight: 646.73
MDL Number: MFCD09837824
Linear Formula: C38H38N4O6
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to light brown |
form |
powder |
InChI |
1S/C38H38N4O6/c1-45-33-18-25-14-16-42(23-28(25)19-34(33)46-2)15-13-24-9-11-29(12-10-24)40-38(44)30-20-35(47-3)36(48-4)21-32(30)41-37(43)27-17-26-7-5-6-8-31(26)39-22-27/h5-12,17-22H,13-16,23H2,1-4H3,(H,40,44)(H,41,43) |
InChI key |
LGGHDPFKSSRQNS-UHFFFAOYSA-N |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O=C(C1=CC(OC)=C(OC)C=C1NC(C2=CC(C=CC=C3)=C3N=C2)=O)NC(C=C4)=CC=C4CCN5CC6=CC(OC)=C(OC)C=C6CC5 |
solubility |
DMSO: 10 mg/mL, clear |
storage temp. |
2-8°C |
Biochem/physiol Actions: |
Specific inhibitor of MDR-1 (P-gp) |
Biochem/physiol Actions: |
Tariquidar is a non-competitive inhibitor. It is used as a potential agent for checking the role of P-glycoprotein inhibition in cancer. Tariquidar also has an ability to enhance drug exposure in drug-resistant cancers. |
Biochem/physiol Actions: |
Tariquidar is a potent MDR1 (P-gp, P-glycoprotein) inhibitor. Tariquidar reverses multidrug resistance (MDR) by inhibiting MDR1-mediated drug efflux. |
Packaging: |
5, 25 mg in glass bottle |
Hazard statements |
H413 |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |