Urolithin A

SIGMA/SML1791 - ≥97% (HPLC)

Synonym: 3,8-Dihydroxy-6H-benzo[c]chromen-6-one

CAS Number: 1143-70-0
Empirical Formula (Hill Notation): C₁₃H₈O₄
Molecular Weight: 228.20
MDL Number: MFCD20275235
Linear Formula: C₁₃H₈O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1791-5MG	5 mg	$114.00 1/EA		Add To Favorites
45-SML1791-25MG	25 mg	$464.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
color	white to beige
form	powder
InChI	1S/C13H8O4/c14-7-1-3-9-10-4-2-8(15)6-12(10)17-13(16)11(9)5-7/h1-6,14-15H
InChI key	RIUPLDUFZCXCHM-UHFFFAOYSA-N
Quality Level	100
SMILES string	OC1=CC=C(C(C=CC(O)=C2)=C2C(O3)=O)C3=C1
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	Urolithin A has been used: • to test its antileukemic activities on leukemic cell lines by in vitro cell proliferation assay • as a mitophagy activator to study the effect of phosphoglycerate mutase 5 (PGAM5) expression on mitophagic cell death during ischemia-reperfusion (I/R) injury • to study its inhibitory effect on epithelial-to-mesenchymal transition (EMT) in lung cancer cells via P53-Mdm2-Snail pathway • to study its effects on streptozotocin-induced diabetic cardiomyopathy in rats by activating sirtuin 1/silent mating type information regulation 2 homolog 1 (SIRT1) signaling
Biochem/physiol Actions:	Urolithin A is a natural product with antiproliferative and antioxidant activity. Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin A has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.
Biochem/physiol Actions:	Urolithin A is the most studied urolithin with anti-inflammatory and anti-obesity properties. It may also prevent the progression of various cancer types including colon, prostate, and bladder cancer by downregulating several oncogenes such as the mammalian target of rapamycin (mTOR) and Kirsten rat sarcoma viral oncogene(K-Ras), upregulating tumor suppressor genes such as p53 and epidermal growth factor receptor (EGFR) in various tumor pathways.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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