Urolithin A
SIGMA/SML1791 - ≥97% (HPLC)
Synonym: 3,8-
CAS Number: 1143-70-0
Empirical Formula (Hill Notation): C13H8O4
Molecular Weight: 228.20
MDL Number: MFCD20275235
Linear Formula: C13H8O4
Product Type: Chemical
| assay | ≥97% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C13H8O4/c14-7-1-3-9-10 |
| InChI key | RIUPLDUFZCXCHM-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | OC1=CC=C(C(C=CC(O)=C2)=C2 |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | Urolithin A has been used: • to test its antileukemic activities on leukemic cell lines by in vitro cell proliferation assay • as a mitophagy activator to study the effect of phosphoglycerate mutase 5 (PGAM5) expression on mitophagic cell death during ischemia-reperfusion (I/R) injury • to study its inhibitory effect on epithelial-to-mesenchymal transition (EMT) in lung cancer cells via P53-Mdm2-Snail pathway • to study its effects on streptozotocin-induced diabetic cardiomyopathy in rats by activating sirtuin 1/silent mating type information regulation 2 homolog 1 (SIRT1) signaling |
| Biochem/physiol Actions: | Urolithin A is a natural product with antiproliferative and antioxidant activity. |
| Biochem/physiol Actions: | Urolithin A is a natural product with antiproliferative and antioxidant activity. Urolithin A is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin A has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease. |
| Biochem/physiol Actions: | Urolithin A is the most studied urolithin with anti-inflammatory and anti-obesity properties. It may also prevent the progression of various cancer types including colon, prostate, and bladder cancer by downregulating several oncogenes such as the mammalian target of rapamycin (mTOR) and Kirsten rat sarcoma viral oncogene(K-Ras), upregulating tumor suppressor genes such as p53 and epidermal growth factor receptor (EGFR) in various tumor pathways. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |