MI-4F
SIGMA/SML1793 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 346460-45-5
Empirical Formula (Hill Notation): C22H17ClFN3S
Molecular Weight: 409.91
Linear Formula: C22H17ClFN3S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | , light yellow to yellow-orange |
form | powder |
Quality Level | 100 ![]() |
SMILES string | FC(C=C1)=CC=C1C=CC2=[N+]( |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | MI-4F is mesoionic compound that exhibits potent anticancer activity against multiple cancer cell lines and in vivo. MI-4F induces apoptosis in HepG2 cells. MI-4F appears to inhibit calcium efflux through inhibition formation of mitochondrial permeability transition pore (MPTP). MI-4F inhibits superoxide dismutase. MI-4F is not susceptible to MDR transporters P-glycoprotein, ABCG2 and MRP1. MI-4F also inhibits ABCG2-mediated efflux of mitoxantrone. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |