Tenofovir disoproxil fumarate
SIGMA/SML1794 - ≥98% (HPLC)
Synonym: Bis(POC)PMPA fumarate; Bis{[(Isopropoxycarbonyl)
CAS Number: 202138-50-9
Empirical Formula (Hill Notation): C19H30N5O10P · C4H4O4
Molecular Weight: 635.51
MDL Number: MFCD08141829
Linear Formula: C19H30N5O10P · C4H4O4
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
InChI | 1S/C19H30N5O10P.C4H4O4/c1 |
InChI key | VCMJCVGFSROFHV-WZGZYPNHSA |
Quality Level | 100 ![]() |
SMILES string | OC(/C=C/C(O)=O)=O.NC1=C2C |
solubility | H2O: 3 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Tenofovir disoproxil fumarate (tenofovir DF) is a nucleotide analogue with activity against retroviruses, such as human immunodeficiency virus (HIV)-1, HIV-2 and hepadnaviruses. |
Biochem/physiol Actions: | Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. In a T cell line and primary blood lymphocytes, the antiviral activity of tenofovir disoproxil was shown to be more than 100-fold greater than tenofovir because of its rapid intracellular uptake. Tenofovir disoproxil fumarate has been used alone and in various combinations for the prevention and treatment of HIV/AIDS and chronic hepatitis B infections and is on the World Health Organization′s List of Essential Medicines. |
Biochem/physiol Actions: | Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI); anti-retroviral. |
Packaging: | 10, 50 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |