Tenofovir
SIGMA/SML1795 - ≥98% (HPLC)
Synonym: (R)
CAS Number: 147127-20-6
Empirical Formula (Hill Notation): C9H14N5O4P
Molecular Weight: 287.21
MDL Number: MFCD00943794
Linear Formula: C9H14N5O4P
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C9H14N5O4P/c1-6(18-5-1 |
| InChI key | SGOIRFVFHAKUTI-ZCFIWIBFSA |
| optical activity | [α]/D -20 to -26°, c = 0.5 in 1 M HCl |
| Quality Level | 100  |
| SMILES string | OP(CO[C@H](C)CN1C2=NC=NC( |
| solubility | H2O: 2 mg/mL, clear (warmed) |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Tenofovir has a low oral bioavailability. Hence, it is available as a prodrug called tenofovir disoproxil fumarate. Once ingested, tenofovir disoproxil fumarate is hydrolyzed to tenofovir and phosphorylated. This is then incorporated into the viral DNA which leads to chain termination. Tenofovir is also effective against hepatitis B virus. |
| Biochem/physiol Actions: | Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. |
| Biochem/physiol Actions: | Tenofovir is a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. Tenofovir is an antiretroviral used for HIV treatment and prevention. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 51111800 |