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L67

SIGMA/SML1797 - ≥98% (HPLC)

Synonym: LigI/III inhibitor L67; N-(3,5-Dibromo-4-methylphenyl)-glycine 2-[(2-hydroxy-5-nitrophenyl)methylene]hydrazide

CAS Number: 325970-71-6
Empirical Formula (Hill Notation): C16H14Br2N4O4
Molecular Weight: 486.11
MDL Number: MFCD00363966
Linear Formula: C16H14Br2N4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1797-5MG 5 mg
 $136.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI key KFEPVFJQVOMODD-IFRROFPPSA-N
Quality Level 100 
SMILES string O=C(N/N=C/C1=CC([N+]([O-])=O)=CC=C1O)CNC2=CC(Br)=C(C)C(Br)=C2
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: L67 is a potent and specific inhibitor of DNA ligase IIIα (LigIIIα) that preferentially targets mitochondrial LigIIIα resulting in mitochondrial dysfunction.
Biochem/physiol Actions: L67 is a potent and specific inhibitor of DNA ligase IIIα (LigIIIα) that preferentially targets mitochondrial LigIIIα resulting in mitochondrial dysfunction. L67 preferentially targets cancer cell mitochondria resulting in enhanced ROS production and caspase 1-dependent apoptosis. L67 in combination with PARP inhibitors decreases survival rate of therapy resistant breast cancer and leukemia cells.
Packaging: 5, 25 mg in glass bottle
Hazard statements H413
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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