JK-2
SIGMA/SML1800 - ≥90% (NMR)
Synonym: Lithium 2-
Empirical Formula (Hill Notation): C15H14NO3PS · 2Li
Molecular Weight: 333.20
Linear Formula: C15H14NO3PS · 2Li
Product Type: Chemical
| assay | ≥90% (NMR) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| SMILES string | S=P(C1=CC=CC=C1)([O-])NC( |
| solubility | H2O: 20 mg/mL, clear |
| storage condition | desiccated |
| protect from light | |
| storage temp. | 2-8°C |
| Biochem/physiol Actions: | JK-2 is a phosphorothioate-based hydrogen sulfide (H2S) donor that shows greatly accelerated H2S release upon protonation-induced intramolecular cyclization at acidic pH ([H2S]/time/pH = 94 μM/4.5 min/pH 5.0, 84 μM/4.5 min/pH 6.0, 36 μM/90 min/pH 7.4, 21 μM/90 min/pH 8.0 with JK-2; [JK-2] = 100 μM at time 0) and is superior to GYY4137 in H2S generation both in buffer (<5 μM H2S/90 min/pH 5.0-8.0 with GYY4137) and in cells without cytotoxicity up to 400 μM in H9c2 and HeLa cultures. JK-2 protects H9c2 rat myoblasts from anoxia/reoxygenation (A/R; 1 hr 2% O2, then 6 hr reoxygenation with 400 μM H2O2) treatment (100% vs. 60% viability with or without 25 μM JK-2) and is efficacious in reducing infarct size per area-at-risk (INF/AAR) upon myocardial ischemia-reperfusion (MI/R) injury induction in mice in vivo (55% and 56% INF/AAR redcution with 50 μg/kg and 100 μg/kg, respectively, via intracardiac injection). |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Purity | ≥90% (NMR) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |