Advanced Search



NVS-CECR2-1

SIGMA/SML1803 - ≥98% (HPLC)

Synonym: Cyclopropyl-{2-(propane-1-sulfonyl)-6-[1-(2,2,6,6-tetramethyl-piperidin-4-yl)-1H-indol-5-yl]-pyrimidin-4-yl}-amine; NVS-1

CAS Number: 1992047-61-6
Empirical Formula (Hill Notation): C27H37N5O2S
Molecular Weight: 495.68
MDL Number: MFCD30290159
Linear Formula: C27H37N5O2S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1803-5MG 5 mg
 $247.00
1/EA		 Add To Favorites
45-SML1803-25MG 25 mg
 $0.00
1/EA
CALL FOR PRICE		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
Quality Level 100 
SMILES string CC(NC(C)(C)C1)(C)CC1N2C=CC3=C2C=CC(C4=NC(S(CCC)(=O)=O)=NC(NC5CC5)=C4)=C3
solubility DMSO: 10 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: NVS-CECR2-1 (NVS-1) is a potent and selective inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2) gene. CECR2 is duplicated in the human disorder cat eye syndrome, which includes defects of the eye, heart, anus, kidney, skeleton, face, and may include mild mental deficiency. CECR2 is involved in neurulation, the folding process that results in the transformation of the neural plate into the neural tube, and is also thought to play a role in DNA damage response. NVS-CECR2-1 (NVS-1) binds to CECR2 with high affinity. It has an IC50 value of 47 nM in Alpha screen and a KD of 80 nM in ITC. NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. For full characterization details, please visit the NVS-CECR2-1 probe summary  on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc 
Features and Benefits: NVS-CECR2-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC .
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Year Price Updates

We are currently working diligently to update our website pricing information for the New Year. If you place an order, you will be acknowledged with any corrected pricing. If you'd like the most current information sooner, please don't hesitate to drop us an email or give us a call and we'd be happy to assist. Thank you for your patience while we are updating.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top