NVS-CECR2-1
SIGMA/SML1803 - ≥98% (HPLC)
Synonym: Cyclopropyl-
CAS Number: 1992047-61-6
Empirical Formula (Hill Notation): C27H37N5O2S
Molecular Weight: 495.68
MDL Number: MFCD30290159
Linear Formula: C27H37N5O2S
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | CC(NC(C)(C)C1)(C)CC1N2C=C |
solubility | DMSO: 10 mg/mL, clear |
storage temp. | −20°C |
Biochem/physiol Actions: | NVS-CECR2-1 (NVS-1) is a potent and selective inhibitor of CECR2 (cat eye syndrome chromosome region, candidate 2) gene. CECR2 is duplicated in the human disorder cat eye syndrome, which includes defects of the eye, heart, anus, kidney, skeleton, face, and may include mild mental deficiency. CECR2 is involved in neurulation, the folding process that results in the transformation of the neural plate into the neural tube, and is also thought to play a role in DNA damage response. NVS-CECR2-1 (NVS-1) binds to CECR2 with high affinity. It has an IC50 value of 47 nM in Alpha screen and a KD of 80 nM in ITC. NVS-CECR2-1 showed no cross reactivity in a BRD panel of 48 targets or any major activity in kinase, protease and receptor panels. For full characterization details, please visit the NVS-CECR2-1 probe summary ![]() ![]() To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc ![]() |
Features and Benefits: | NVS-CECR2-1 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC ![]() |
Features and Benefits: | This compound is a featured product for Gene Regulation research. Click here ![]() ![]() |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | −20°C |
UNSPSC | 12352200 |