IMR-1

SIGMA/SML1812 - ≥98% (HPLC)

Synonym: 2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester; Inhibitor of Mastermind Recruitment-1

CAS Number: 310456-65-6
Empirical Formula (Hill Notation): C₁₅H₁₅NO₅S₂
Molecular Weight: 353.41
Linear Formula: C₁₅H₁₅NO₅S₂
Product Type: Chemical

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C15H15NO5S2/c1-3-20-13(17)8-21-10-5-4-9(6-11(10)19-2)7-12-14(18)16-15(22)23-12/h4-7H,3,8H2,1-2H3,(H,16,18,22)
InChI key	QHPJWPQRZMBKTG-UHFFFAOYSA-N
Quality Level	100
SMILES string	O=C(OCC)COC1=CC=C(C=C2SC(NC2=O)=S)C=C1OC
solubility	DMSO: 20 mg/mL, clear
storage temp.	2-8°C

Application:	Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells.
Biochem/physiol Actions:	IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A.
Biochem/physiol Actions:	IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable