IMR-1
SIGMA/SML1812 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 310456-65-6
Empirical Formula (Hill Notation): C15H15NO5S2
Molecular Weight: 353.41
Linear Formula: C15H15NO5S2
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| SMILES string | O=C(OCC)COC1=CC=C(C=C2SC( |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | 2-8°C |
| Application: | Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells. |
| Biochem/physiol Actions: | IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |