IMR-1
SIGMA/SML1812 - ≥98% (HPLC)
Synonym: 2-
CAS Number: 310456-65-6
Empirical Formula (Hill Notation): C15H15NO5S2
Molecular Weight: 353.41
Linear Formula: C15H15NO5S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
Quality Level | 100 ![]() |
SMILES string | O=C(OCC)COC1=CC=C(C=C2SC( |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Application: | Inhibitor of mastermind recruitment-1 (IMR-1) has been used as an inhibitor of Notch transcription activation complex to downregulate the expression of Notch and downstream protein in pheochromocytoma (PC -12) cells. |
Biochem/physiol Actions: | IMR-1 is a cell penetrant and potent inhibitor of Notch transcriptional activation complex that disrupted the recruitment of Mastermind-like 1 (Maml1) to the Notch transcriptional activation complex on chromatin. IMR-1 potently inhibits the growth of Notch-dependent cancer cell lines, and inhibits growth of patient-derived tumor xenografts. IMR-1 is hydrolyzed in vivo to acid metabolite IMR-1A. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H315 - H319 - H335 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |