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BCI-121

SIGMA/SML1817 - ≥98% (HPLC)

Synonym: 4-(Aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide; BCI121

CAS Number: 432529-82-3
Empirical Formula (Hill Notation): C14H18BrN3O2
Molecular Weight: 340.22
Linear Formula: C14H18BrN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1817-5MG 5 mg
 $106.00
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45-SML1817-25MG 25 mg
 $434.00
1/EA		 Add To Favorites
This image is provided for informative purposes only and does not represent an actual product label. It should not be used as a substitute for official product labeling.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C14H18BrN3O2/c15-11-1-3-12(4-2-11)17-13(19)9-18-7-5-10(6-8-18)14(16)20/h1-4,10H,5-9H2,(H2,16,20)(H,17,19)
InChI key KSUYPIXCRPCPGF-UHFFFAOYSA-N
Quality Level 100 
SMILES string Brc1ccc(cc1)NC(=O)CN2CCC(CC2)C(=O)N
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: BCI-121 is a substrate-competitive SMYD3 inhibitor that reduces nuclear histone H3 lys4 di- and tri-methylation level (by 50%/H3K4me2 and 40%H3K4me3 in HT29 cells; 100 μM BCI-121 for 48 h), downregulates known SMYD3 target genes transcription, and selectively affects SMYD3-dependent proliferation of cancer cultures (46%/HT29 and 54%/HCT116 proliferation reduction; 100 μM BCI-121 for 72 h) with little antiproliferation efficacy toward low SMYD3-expressing cancer cells. BCI-121 targets SMYD3 via direct affinity interaction (kon 357.7/M/s; koff 4.23×10-3/s; KD=koff/kon = 11.8 μM) and effectively competes against histone for SMYD3 binding (%inhibition/[histone H4 peptide]:[BCI-121] ratio = 36.5%/1:1 and 51.0%/1:2.5).
Biochem/physiol Actions: BCI-121 is a substrate-competitive SMYD3 inhibitor.
Biochem/physiol Actions: BCI121 is capable of reducing the mesenchymal signature of MDA-MB-231 cells. It can also decrease their ability to invade in vitro and in vivo.
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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