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Akebia saponin D

SIGMA/SML1822 - ≥98% (HPLC)

Synonym: 3-O-α-L-arabinopyranosyl hederagenin-28-β-D-glucopyranoside-(1→6)-β-D-glucopyranoside; ASD; Asperosaponin VI; Leiyemudanoside A; Tauroside St-G0-1

CAS Number: 39524-08-8
Empirical Formula (Hill Notation): C47H76O18
Molecular Weight: 929.10
Linear Formula: C47H76O18
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1822-5MG 5 mg
 $114.00
1/EA		 Add To Favorites
45-SML1822-25MG 25 mg
 $464.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
biological source (Dipsacus asper)
color white to beige
form powder
InChI 1S/C47H76O18/c1-42(2)13-15-47(41(59)65-40-37(58)34(55)32(53)26(63-40)20-61-38-36(57)33(54)31(52)25(18-48)62-38)16-14-45(5)22(23(47)17-42)7-8-28-43(3)11-10-29(64-39-35(56)30(51)24(50)19-60-39)44(4,21-49)27(43)9-12-46(28,45)6/h7,23-40,48-58H,8-21H2,1-6H3/t23-,24-,25+,26+,27+,28+,29-,30-,31+,32+,33-,34-,35+,36+,37+,38+,39-,40-,43-,44-,45+,46+,47-/m0/s1
InChI key CCRXMHCQWYVXTE-HMRSNRLKSA-N
optical activity [α]/D +13 to +18°, c = 0.5 in methanol
Quality Level 100 
shipped in wet ice
SMILES string CC1(C)CC[C@]2(C(O[C@@H]3O[C@H](CO[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](O)[C@H](O)[C@H]3O)=O)CC[C@@]5(C)[C@]6(C)CCC7[C@](C)(CO)[C@@H](O[C@]8([H])OC[C@H](O)[C@H](O)[C@H]8O)CC[C@]7(C)[C@@]6([H])CC=C5[C@]2([H])C1
solubility H2O: 3 mg/mL, clear (warmed)
storage condition desiccated
storage temp. −20°C
Biochem/physiol Actions: Akebia saponin D (ASD) is a bioactive triterpenoid saponin isolated from the rhizome of Dipsacus asper Wall that is used as an anti-osteoporosis drug. Akebia saponin D exhibits therapeutic effects in number of disease models including cancer, Alzheimer′s disease, cardiovascular disease, and bone fractures. Akebia saponin D protects against nonalcoholic fatty liver disease (NAFLD) liver damage in mice model of NAFLD. ASD decreases hepatic steatosis and heptocyte apoptosis through autophagy modulation. Akebia saponin D prevents oleic acid induced lipid droplets accumulation and increases autophagic flux BRL cells.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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