Synonym: 1,4-Dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid hydrochloride; SNS-595 hydrochloride; Voreloxin hydrochloride
CAS Number: 175519-16-1
Empirical Formula (Hill Notation): C18H19N5O4S · HCl
Molecular Weight: 437.90
MDL Number: MFCD13185156
Linear Formula: C18H19N5O4S · HCl
Product Type: Chemical
assay |
≥98% (HPLC) |
color |
white to beige |
form |
powder |
optical activity |
[α]/D +42 to +52°, c = 1 in 0.1 M NaOH |
Quality Level |
100 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O=C(C(C(O)=O)=C1)C2=C(N=C(C=C2)N3C[C@@H]([C@H](C3)NC)OC)N1C4=NC=CS4 |
solubility |
H2O: 1 mg/mL, clear (warmed) |
storage temp. |
−20°C |
Biochem/physiol Actions: |
Vosaroxin is an anti-cancer quinolone derivative that acts as a DNA intercalator and a topoisomerase II inhibitor, causing p53 independent tumor cell apoptosis. Vosaroxin stabilizes cleavage complexes formed by topoisomerase IIα and IIβ, which results in an accumulation of DNA double-strand breaks. Vosaroxin showed antineoplastic activity in multiple solid tumor and hematologic cancer cell lines and has been in clinical trials for AML. |
Packaging: |
5, 25 mg in glass bottle |
RIDADR |
NONH for all modes of transport |
WGK Germany |
WGK 3 |
Flash Point(F) |
Not applicable |
Flash Point(C) |
Not applicable |
Purity |
≥98% (HPLC) |
Storage Temp. |
−20°C |
UNSPSC |
12352200 |