GSK983

SIGMA/SML1824 - ≥98% (HPLC)

Synonym: GSK260983; N-[(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide

CAS Number: 827591-02-6
Empirical Formula (Hill Notation): C₁₈H₁₆ClN₃O
Molecular Weight: 325.79
MDL Number: MFCD28978021
Linear Formula: C₁₈H₁₆ClN₃O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1824-5MG	5 mg	$163.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C18H16ClN3O/c19-11-7-8-14-13(10-11)12-4-3-6-15(17(12)21-14)22-18(23)16-5-1-2-9-20-16/h1-2,5,7-10,15,21H,3-4,6H2,(H,22,23)
InChI key	WJQBOBGVBBZLJU-UHFFFAOYSA-N
optical activity	[α]/D +175 to +195°, c = 1 in methylene chloride
Quality Level	100
SMILES string	ClC1=CC=C(NC2=C3CCC[C@H]2NC(C4=NC=CC=C4)=O)C3=C1
solubility	DMSO: 10 mg/mL, clear
storage condition	protect from light
storage temp.	2-8°C

Biochem/physiol Actions:	GSK983 blocks RNA virus replication with EC₅₀ values of 10–40 nM, and also blocks cell proliferation.
Biochem/physiol Actions:	GSK983 blocks RNA virus replication with EC₅₀ values of 10–40 nM, and also blocks cell proliferation. GSK983 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses.
Biochem/physiol Actions:	GSK983 is a tetrahydrocarbazole or a broad spectrum antiviral lead compound. GSK983 acts by stimulating a subset of interferon-stimulated genes.
Packaging:	5, 25 mg in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302 - H315 - H319
Precautionary statements	P301 + P312 + P330 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51111800

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