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GSK983

SIGMA/SML1824 - ≥98% (HPLC)

Synonym: GSK260983; N-[(1R)-6-Chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-2-pyridinecarboxamide

CAS Number: 827591-02-6
Empirical Formula (Hill Notation): C18H16ClN3O
Molecular Weight: 325.79
MDL Number: MFCD28978021
Linear Formula: C18H16ClN3O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1824-5MG 5 mg
 $163.00
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This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts SML1824-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H16ClN3O/c19-11-7-8-14-13(10-11)12-4-3-6-15(17(12)21-14)22-18(23)16-5-1-2-9-20-16/h1-2,5,7-10,15,21H,3-4,6H2,(H,22,23)
InChI key WJQBOBGVBBZLJU-UHFFFAOYSA-N
optical activity [α]/D +175 to +195°, c = 1 in methylene chloride
Quality Level 100 
SMILES string ClC1=CC=C(NC2=C3CCC[C@H]2NC(C4=NC=CC=C4)=O)C3=C1
solubility DMSO: 10 mg/mL, clear
storage condition protect from light
storage temp. 2-8°C
Biochem/physiol Actions: GSK983 blocks RNA virus replication with EC50 values of 10–40 nM, and also blocks cell proliferation.
Biochem/physiol Actions: GSK983 blocks RNA virus replication with EC50 values of 10–40 nM, and also blocks cell proliferation. GSK983 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses.
Biochem/physiol Actions: GSK983 is a tetrahydrocarbazole or a broad spectrum antiviral lead compound. GSK983 acts by stimulating a subset of interferon-stimulated genes.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 51111800

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