GSK984
SIGMA/SML1825 - ≥98% (HPLC)
Synonym: N-
CAS Number: 827591-04-8
Empirical Formula (Hill Notation): C18H16ClN3O
Molecular Weight: 325.79
Linear Formula: C18H16ClN3O
Product Type: Chemical
assay | ≥98% (HPLC) |
color | white to beige |
form | powder |
optical activity | [α]/D -175 to -195°, c = 1 in methylene chloride |
Quality Level | 100 ![]() |
SMILES string | ClC1=CC=C(NC2=C3CCC[C@@H] |
solubility | DMSO: 20 mg/mL, clear |
storage condition | protect from light |
storage temp. | 2-8°C |
Biochem/physiol Actions: | GSK984 is an inactive control probe for GSK983, which is an inhibitor of dihydroorotate dehydrogenase (DHODH) with antiviral activity. GSK983 blocks RNA virus replication with EC50 values of 10–40 nM, and also blocks cell proliferation. GSK984 acts by inhibition of dihydroorotate dehydrogenase (DHODH), necesssary for pyrimidine biosynthesis. Exogenous deoxycytidine was able to reduce GSK983 cytotoxicity, allowing cells to synthesize DNA, but still preventing RNA virus replication. GSK983 was active against dengue fever and Venezuelan equine encephalitis viruses. GSK984, the (S)-isomer, is almost 200-fold less active, so would make a good control. |
Packaging: | 5, 25 mg in glass bottle |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 - H315 - H319 |
Precautionary statements | P301 + P312 + P330 - P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |