KYA1797K potassium salt
SIGMA/SML1831 - ≥98% (HPLC)
Synonym: (5Z)
CAS Number: 1956356-56-1
Empirical Formula (Hill Notation): C17H11KN2O6S2
Molecular Weight: 442.51
Linear Formula: C17H11KN2O6S2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | orange to dark red |
form | powder |
Quality Level | 100 ![]() |
SMILES string | [O-]C(CCN1C(/C(SC1=S)=C/C |
solubility | DMSO: 2 mg/mL, clear (warmed) |
storage temp. | 2-8°C |
Biochem/physiol Actions: | KYA1797K is an inhibitor of both Wnt/β-catenin and Ras pathways. It binds to the axin regulators of the G-protein signaling (RGS) domain enhancing formation of the β-catenin destruction complex and inducing activation GSK3β, which results in phosphorylation and subsequent degradation of both β-catenin and K-Ras. KYA1797K was show to suppress tumor growth and progression in mouse xenografts of CRC cells that had APC and K-Ras mutations. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |