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ML385

SIGMA/SML1833 - ≥98% (HPLC)

Synonym: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

CAS Number: 846557-71-9
Empirical Formula (Hill Notation): C29H25N3O4S
Molecular Weight: 511.59
Linear Formula: C29H25N3O4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1833-5MG 5 mg
 $117.00
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45-SML1833-25MG 25 mg
 $477.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C29H25N3O4S/c1-17-5-3-4-6-22(17)28(34)32-12-11-20-15-21(8-9-23(20)32)27-18(2)37-29(31-27)30-26(33)14-19-7-10-24-25(13-19)36-16-35-24/h3-10,13,15H,11-12,14,16H2,1-2H3,(H,30,31,33)
InChI key LINHYWKZVCNAMQ-UHFFFAOYSA-N
Quality Level 100 
SMILES string O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
solubility DMSO: 10 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.
Biochem/physiol Actions: ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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