ML385

SIGMA/SML1833 - ≥98% (HPLC)

Synonym: N-[4-[2,3-Dihydro-1-(2-methylbenzoyl)-1H-indol-5-yl]-5-methyl-2-thiazolyl]-1,3-benzodioxole-5-acetamide

CAS Number: 846557-71-9
Empirical Formula (Hill Notation): C₂₉H₂₅N₃O₄S
Molecular Weight: 511.59
Linear Formula: C₂₉H₂₅N₃O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1833-5MG	5 mg	$114.00 1/EA	Add To Favorites
45-SML1833-25MG	25 mg	$464.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
Quality Level	100
SMILES string	O=C(NC1=NC(C2=CC=C(N(C(C3=C(C)C=CC=C3)=O)CC4)C4=C2)=C(C)S1)CC5=CC(OCO6)=C6C=C5
solubility	DMSO: 10 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

ML385 inihbits the activity of the Nrf2 transcription factor by binding to Neh1, a CNC-bZIP domain that allows Nrf2 to heterodimerize with small Maf proteins, blocking NRF2 transcriptional activity. Much research has been done on activating Nrf2 because it induces cytoprotective antioxidant genes. However, some cancer cells may use Nrf2 similarly for their survival. Nrf2 is overexpressed in certain cancers such as non-small cell lung cancer (NSCLC) often due to loss of function mutations in KEAP1, which targets Nrf2 for proteasomal degradation. ML385 was found to have anti-tumor activity with specificity and selectivity for NSCLC cells with KEAP1 mutations.

Packaging:

5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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