PFM39

SIGMA/SML1839 - ≥98% (HPLC)

Synonym: (5Z)-2-Amino-5-[(4-aminophenyl)methylene]-4(5H)-thiazolone; 5-(4-Aminobenzylidene)-2-iminothiazolidin-4-one

CAS Number: 1310744-67-2
Empirical Formula (Hill Notation): C₁₀H₉N₃OS
Molecular Weight: 219.26
Linear Formula: C₁₀H₉N₃OS
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1839-5MG	5 mg	$142.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow to orange
form	powder
InChI	1S/C10H9N3OS/c11-7-3-1-6(2-4-7)5-8-9(14)13-10(12)15-8/h1-5H,11H2,(H2,12,13,14)/b8-5-
InChI key	QXOIZYPBCJHYLN-YVMONPNESA-N
Quality Level	100
SMILES string	NC1=CC=C(/C=C2SC(NC2=O)=N)C=C1
solubility	DMSO: 15 mg/mL, clear
storage temp.	2-8°C

Biochem/physiol Actions:

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity.

Biochem/physiol Actions:

PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR).

Symbol	GHS07
Signal word	Warning
Hazard statements	H319
Precautionary statements	P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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