PFM39
SIGMA/SML1839 - ≥98% (HPLC)
Synonym: (5Z)
CAS Number: 1310744-67-2
Empirical Formula (Hill Notation): C10H9N3OS
Molecular Weight: 219.26
Linear Formula: C10H9N3OS
Product Type: Chemical
assay | ≥98% (HPLC) |
color | yellow to orange |
form | powder |
Quality Level | 100 ![]() |
SMILES string | NC1=CC=C(/C=C2SC(NC2=O)= |
solubility | DMSO: 15 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | PFM39 is a potent cell-permeable Mirin analog that selectively inhibits MRE11 exo-, but not endo-, nuclease activity. PFM39 targets MRE11 in a fashion similar to Mirin, but distinct from that of PFM01 to allow a blockage of dsDNA phosphate backbone rotation and selective inhibition against MRE11 exo-, but not endo-, nuclease activity. FM39 potently impairs G2-phase double-strand break (DSB) repair in 1BR3-hTERT fibrolasts following ionizing irradiation (IR). |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H319 |
Precautionary statements | P305 + P351 + P338 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |