Ibuprofen Arginate

SIGMA/SML1842 - ≥98% (HPLC)

Synonym: α-Methyl-4-(2-methylpropyl)benzeneacetate, L-arginine (1:1); (S)-1-(4-Amino-4-carboxybutyl)guanidinium 2-(4-isobutylphenyl)propanoate; Ibu-L-Arg; Ibuprofen L-arginine; Ibuprofen arginine

CAS Number: 57469-82-6
Empirical Formula (Hill Notation): C₁₉H₃₂N₄O₄
Molecular Weight: 380.48
Linear Formula: C₁₉H₃₂N₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SML1842-25MG	25 mg	$328.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C13H18O2.C6H14N4O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;7-4(5(11)12)2-1-3-10-6(8)9/h4-7,9-10H,8H2,1-3H3,(H,14,15);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t;4-/m.0/s1
InChI key	GCCOJNYCFNSJII-VWMHFEHESA-N
Quality Level	100
SMILES string	CC(CC1=CC=C(C(C([O-])=O)C)C=C1)C.O=C(O)[C@@H](N)CCCNC([NH3+])=N
solubility	H₂O: 20 mg/mL, clear
storage temp.	−20°C

Biochem/physiol Actions:	Ibuprofen arginate is the more soluble arginate salt form of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen.
Biochem/physiol Actions:	Ibuprofen arginate is the more soluble arginate salt form of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. Ibuprofen arginate retains the inhibitory potency against COX-2 as ibuprofen and its sodium salt, however only ibuprofen arginate is able to augment cellular NO pathway through codelivery of the NOS substrate arginine. Ibuprofen arginate, but not the sodium salt form, is shown to reverse the inhibitory effects of the cardiotoxic hormone asymmetric dimethylarginine (ADMA) and NG-nitro-L-argininemethyl ester (L-NAME) against nitric oxide synthase (eNOS & iNOS) in cultures in vitro (Murine RAW264.7 macrophages and isolated mouse & rat aorta) and effectively prevent L-NAME-induced arterial blood pressure increase in anesthetized rats in vivo (0.5 mg/kg L-NAME; 114.8 μmol/kg ibuprofen arginate, equivalent to 20 mg/kg L-Arg via femoral artery cannulation).
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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