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Ibuprofen Arginate

SIGMA/SML1842 - ≥98% (HPLC)

Synonym: α-Methyl-4-(2-methylpropyl)benzeneacetate, L-arginine (1:1); (S)-1-(4-Amino-4-carboxybutyl)guanidinium 2-(4-isobutylphenyl)propanoate; Ibu-L-Arg; Ibuprofen L-arginine; Ibuprofen arginine

CAS Number: 57469-82-6
Empirical Formula (Hill Notation): C19H32N4O4
Molecular Weight: 380.48
Linear Formula: C19H32N4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1842-25MG 25 mg
 $328.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C13H18O2.C6H14N4O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;7-4(5(11)12)2-1-3-10-6(8)9/h4-7,9-10H,8H2,1-3H3,(H,14,15);4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t;4-/m.0/s1
InChI key GCCOJNYCFNSJII-VWMHFEHESA-N
Quality Level 100 
SMILES string CC(CC1=CC=C(C(C([O-])=O)C)C=C1)C.O=C(O)[C@@H](N)CCCNC([NH3+])=N
solubility H2O: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: Ibuprofen arginate is the more soluble arginate salt form of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen.
Biochem/physiol Actions: Ibuprofen arginate is the more soluble arginate salt form of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen. Ibuprofen arginate retains the inhibitory potency against COX-2 as ibuprofen and its sodium salt, however only ibuprofen arginate is able to augment cellular NO pathway through codelivery of the NOS substrate arginine. Ibuprofen arginate, but not the sodium salt form, is shown to reverse the inhibitory effects of the cardiotoxic hormone asymmetric dimethylarginine (ADMA) and NG-nitro-L-argininemethyl ester (L-NAME) against nitric oxide synthase (eNOS & iNOS) in cultures in vitro (Murine RAW264.7 macrophages and isolated mouse & rat aorta) and effectively prevent L-NAME-induced arterial blood pressure increase in anesthetized rats in vivo (0.5 mg/kg L-NAME; 114.8 μmol/kg ibuprofen arginate, equivalent to 20 mg/kg L-Arg via femoral artery cannulation).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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