EPI-001
SIGMA/SML1844 - ≥98% (HPLC)
Synonym: 3-
CAS Number: 227947-06-0
Empirical Formula (Hill Notation): C21H27ClO5
Molecular Weight: 394.89
MDL Number: MFCD02683414
Linear Formula: C21H27ClO5
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| InChI | 1S/C21H27ClO5/c1-21(2,15- |
| InChI key | HDTYUHNZRYZEEB-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | ClCC(O)COc1ccc(cc1)C(C)(C |
| solubility | DMSO: 15 mg/mL, clear |
| storage temp. | −20°C |
| Biochem/physiol Actions: | EPI-001 is a specific inhibitor of the AR (androgen receptor) without inhibiting PR or GR transcriptional activities. |
| Biochem/physiol Actions: | EPI-001 is a specific inhibitor of the AR (androgen receptor) without inhibiting PR or GR transcriptional activities. EPI-001 selectively interacts with transactivation unit 5 (Tau-5) of the androgen receptor, which is essential for prostate cells to proliferate in the absence of androgens. EPI-001 is active against castration-resistant prostate cancer (CRPC) in xenografts. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |