Synonym: CHEBI:9516; CHEMBL96926; MFCD00083511; UNII-Z96BQ26RZD; Z96BQ26RZD; [(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate
CAS Number: 67526-95-8
Empirical Formula (Hill Notation): C34H50O12
Molecular Weight: 650.75
Linear Formula: C34H50O12
Product Type: Chemical
| assay |
≥98% (HPLC) |
| biological source |
(Thapsia garganica L seeds) |
| concentration |
10 mM in DMSO |
| form |
DMSO solution |
| InChI |
1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1 |
| InChI key |
IXFPJGBNCFXKPI-FSIHEZPISA-N |
| Quality Level |
200  |
| shipped in |
dry ice |
| storage temp. |
−20°C |
| Application: |
Thapsigargin Ready Made Solution has been used as a negative control in in vivo growth and in vitro translation measurements. |
| Biochem/physiol Actions: |
Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues. |
| Biochem/physiol Actions: |
Thapsigargin is an effective inhibitor of calcium ion pumps located on sarcoplasmic reticulum (SR) and endoplasmic reticulum (ER) microsomes of skeletal, cardiac, muscle and brain tissues. The inhibition of calcium ion pumps causes intracellular increase of calcium ion levels. It was found that thapsigargin at 100 nM concentration effectively inhibited the SR Ca2+- adenosine triphosphatase (ATPase) in cardiac and skeletal muscles. Thapsigargin was also reported to be effective in blocking autophagy by interfering with the autophagosome-lysosome fusion. |
| Other Notes: |
Thapsigargin Ready Made Solution is provided at 10 mM concentration in DMSO. The solution can be further diluted with DMSO to a concentration of 2 mM. It is recommended to store Thapsigargin Ready Made Solution in small aliquots at -20 °C. |
| WGK Germany |
WGK 2 |
| Flash Point(F) |
188.6 °F - closed cup |
| Flash Point(C) |
87 °C - closed cup |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
−20°C |
| UNSPSC |
12352200 |
