RI(dl)-2
SIGMA/SML1851 - ≥98% (HPLC)
Synonym: N-
CAS Number: 1902146-75-1 (free base)
Empirical Formula (Hill Notation): C19H17N3 · xC2HF3O2
Molecular Weight: 287.36 (free base basis)
Linear Formula: C19H17N3 · xC2HF3O2
Product Type: Chemical
assay | ≥98% (HPLC) |
color | , light orange to dark red |
form | powder |
Quality Level | 100 ![]() |
SMILES string | CCNC1=CC=C(C2=NC3=C(N4C2= |
solubility | DMSO: 20 mg/mL, clear |
storage temp. | 2-8°C |
Biochem/physiol Actions: | RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 μM) without affecting its ssDNA-binding activity (IC50 >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity. |
Packaging: | 5, 25 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |