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RI(dl)-2

SIGMA/SML1851 - ≥98% (HPLC)

Synonym: N-Ethyl-4-(pyrrolo[1,2-a]quinoxalin-4-yl)aniline

CAS Number: 1902146-75-1 (free base)
Empirical Formula (Hill Notation): C19H17N3 · xC2HF3O2
Molecular Weight: 287.36 (free base basis)
Linear Formula: C19H17N3 · xC2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-SML1851-5MG 5 mg
 $105.00
1/EA		 Add To Favorites
45-SML1851-25MG 25 mg
 $424.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color , light orange to dark red
form powder
Quality Level 100 
SMILES string CCNC1=CC=C(C2=NC3=C(N4C2=CC=C4)C=CC=C3)C=C1.FC(F)(C(O)=O)F
solubility DMSO: 20 mg/mL, clear
storage temp. 2-8°C
Biochem/physiol Actions: RI(dl)-2 is a cell-permeable pyrroloquinoxaline derivative that selectively inhibits Rad51-mediated D-loop formation (IC50 = 11.1 μM) without affecting its ssDNA-binding activity (IC50 >100 μM). RI(dl)-2 is shown to inhibit DSBs-induced cellular homologous recombination (HR) activity (IC50 = 3.0 μM by HEK293-based DR-GFP reporter assay) by stabilizing nucleoprotein filaments in a nonfunctional state without affecting DNA damage-induced RAD51 nuclear loci formation or stimulating single-strand annealing (SSA) activity.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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