8-Aminoguanosine

SIGMA/SML1852 - ≥98% (HPLC)

Synonym: 2,8-Diamino-inosine; NSC 90390

CAS Number: 3868-32-4
Empirical Formula (Hill Notation): C₁₀H₁₄N₆O₅
Molecular Weight: 298.26
Linear Formula: C₁₀H₁₄N₆O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-SML1852-25MG	25 mg	$71.50 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to brown
form	powder
InChI	1S/C10H14N6O5/c11-9-14-6-3(7(20)15-9)13-10(12)16(6)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H2,12,13)(H3,11,14,15,20)
InChI key	FNXPTCITVCRFRK-UHFFFAOYSA-N
Quality Level	100
SMILES string	NC1=NC(C2=C(N1)N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N2)=O
solubility	DMSO: 1 mg/mL, clear (warmed)
storage temp.	2-8°C

Biochem/physiol Actions:	8-Aminoguanosine is known to stimulate diuresis, natriuresis, glucosuria and antikaliuresis. It is an analog of guanosine, that can block purine nucleoside phosphorylase, in vitro and in intact lymphoid cells. 8-aminoguanosine triphosphate can be used to block GTP (guanosine triphosphate) cyclohydrolase I from human liver and Escherichia coli.
Biochem/physiol Actions:	8-Aminoguanosine, a guanosine derivative, is an orally available and highly efficacious potassium-sparing diuretic/natriuretic that increased sodium excretion by 26.2-fold and decrease potassium excretion by 69.1%. 8-Aminoguanosine increases glucose excretion by 12.2-fold. Also 8-Aminoguanosine suppressed deoxycorticosterone/salt-induced hypertension.
Biochem/physiol Actions:	Orally available and highly efficacious potassium-sparing diuretic/natriuretic
Packaging:	25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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