Synonym: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedione; AQ4N dihydrochloride
CAS Number: 252979-56-9
Empirical Formula (Hill Notation): C22H28N4O6 · 2HCl
Molecular Weight: 517.40
MDL Number: MFCD19690955
Linear Formula: C22H28N4O6 · 2HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
blue |
| form |
powder |
| InChI |
1S/C22H28N4O6.2ClH/c1-25(2,31)11-9-23-13-5-6-14(24-10-12-26(3,4)32)18-17(13)21(29)19-15(27)7-8-16(28)20(19)22(18)30;;/h5-8,23-24,27-28H,9-12H2,1-4H3;2*1H |
| InChI key |
SBWCPHUXRZRTDP-UHFFFAOYSA-N |
| Quality Level |
100  |
| SMILES string |
O=C1C2=C(C(NCC[N+](C)([O-])C)=CC=C2NCC[N+]([O-])(C)C)C(C3=C(O)C=CC(O)=C31)=O.[H]Cl.[H]Cl |
| solubility |
H2O: 3 mg/mL, clear (warmed) |
| storage condition |
desiccated |
| storage temp. |
2-8°C |
| Application: |
Banoxantrone dihydrochloride has been used as an organic ligand during a self-assembled metal-organic coordinated nanoparticle (Cu–OCNP/Lap) synthesis. It has also been used for the preparation of supramolecularly functionalized graphene oxide for hypoxia-activated chemotherapy of cancer. |
| Biochem/physiol Actions: |
Banoxantrone (AQ4N) is a hypoxia-activated prodrug of topoisomerase II inhibitor AQ4 (Bioreductive AQ4 precursor). |
| Biochem/physiol Actions: |
Banoxantrone dihydrochloride enhances the anti-tumor effect caused by radiation. |
| Biochem/physiol Actions: |
Hypoxia-activated prodrug of topoisomerase II inhibitor AQ4 |
| Packaging: |
5, 25 mg in glass bottle |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
